Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

Benign prostatic hyperplasia (BPH) and prostate adenocarcinoma are the most common disorders affecting elderly men. The diseases androgen-dependent treated by obstructing androgen receptor (AR) or their action. AR has direct relationship between development of carcinoma. Estrogens directly target tissue definite estrogen receptors (ER). human is primed with a dual system ERs (ER-α ER-β). Use estrogens as hormonal agents for suppressing growth. Study aims to identify, assess establish significance ER marker in distinguishing BPH A cross sectional study was conducted at tertiary care hospital over period two year on 65 specimens which included 30 malignant cases 35 benign cases. Specimens received were tru-cut biopsy, transurethral resection chips (TURP) prostatectomy specimen TURP lesions. Paraffin embedded blocks stained H&E IHC performed representative sections graded .the results assessed association various parameters both Out majority needle biopsies (54%). age presentation 55-84 years mean being 68.93 years. In presenting 35-84 63 Histopathological lesions, showed negative correlation grade group PNI positive neutrophils. Higher adverse histological parameters. %PSA <25% malignancy. positivity noted 80% 100% weaker maximum all malignant, showing higher intensity. Hormones play multifactorial role pathogenesis carcinoma; commonly estrogen, can be used towards finding better therapy.